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丁先玲 (Ding, Shian-ling, Ph.D.)



  護理健康學院 院長


  TEL: 886-2-26321181# 585

  Fax: 886-2-23649857














英國長照實務增能研習(Canterbury Christ Church University)














 1. 國科會研究計畫

名 稱




經 費(元)

台灣地區婦女衰老基因WRN 多型性與乳癌易感受性的相關分析-病例對照研究(2年)

Breast Cancer Risk Associated with Genotypic Polymorphism of the Premature Aging Gene, WRN:A Case-Control Study on Cancer Susceptibility


95/08/01 ~ 96/07/31




Haplotype Analysis of Single Nucleotide Polymorphisms in Estrogen Receptor AlphaESR1Gene for Breast Cancer Risk: A Large Case-Control Study on Cancer Susceptibility.


96/08/01 ~ 98/07/31




Breast cancer risk associated with the genetic polymorphism of putative tumor suppression gene, FBXW7/CDC4, in relation to its expression profiles: emphasis on clinicopathological features and prognostic outcomes


98/08/01 ~101/07/31



    2. 中研院獎勵國內學人短期來院訪問研究計畫


Genetic Variation in the Premature Aging Gene, WRN A Case-Control Study on Breast Cancer Susceptibility


94/07/01 ~ 94/12/31



 3. 國際學術會議 (論文發表)

─ American Association for Cancer Research (AACR) Annual Meeting 2007 in San Diego, CA, USA

─ American Association for Cancer Research (AACR) Annual Meeting 2008 in San Diego, CA, USA

─ Kyoto Breast Cancer Consensus Conference International Convention 2009 in Kyoto, Japan

─ American Association for Cancer Research (AACR) Annual Meeting 2010 in Washington, DC, USA

─ American Association for Cancer Research (AACR) Annual Meeting 2012,  in Chicago, Illinois, USA

 4. 國內學術會議

台灣流行病學學會/SNP-based Association Study Work Shops 台北醫學院教研大樓1F, 2004-9-11 (專題: Linkage Disequilibrium and Haplotype Analysis

─ 第五屆生命科學研究所論文研討會Aspire learning & recreation center (Title: Molecular mechanism underlying early-onset breast cancer), June-23-2004.

 5. 國際性學術刊物邀稿─ Review for Clinical Interventions in Aging期刊(Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes. Clinical Interventions in Aging 2008; 3(3): 1–14.

 6. 國際性SCI學術刊物審稿─ Molecular MedicineImpact Factor3.349

 7. 國內學術刊物審稿─ 護理雜誌




Molecular Mechanism Underlying Early-onset Breast Cancer(<35歲女性早發性乳癌的分子機制)



Risk Factors of Preterm Delivery of Tri-Service General Hospital-A Case-Control Study(早產危險因子)


  1. Lin WY, et al. (Ding SL is listed as the 193rd author among 221 authors) Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet  2015;24:285-298. (SCI; Impact Factor =8.058)
  2. Michailidou K, et al., (Ding SL is listed as the 206th author among 224 authors ) Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 2013;45:353-61. (SCI; Impact Factor = 35.209).
  3. Cheng CW, Liu YF, Yu JC, Wang HW, Ding SL, Hsiung CN, Hsu HM, Shieh JC, Wu PE, Shen CY. Prognostic significance of cyclin D1, β-catenin, and MTA1 in patients with invasive ductal carcinoma of the breast. Ann Surg Oncol 2012;19(13):4129-39. (SCI; Impact Factor = 4.12).
  4. Cheng CW, Wang HW, Chang CW, Chu HW, Chen CY, Yu JC, Chao JI, Liu HF, Ding SL, Shen CY. MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Res Treat 2012;134(3):1081-93. (SCI; Impact Factor = 4.469).
  5. Figueroa JD, et al., (Ding SL is listed as the 133rd author among 147 authors). Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet 2011;20:4693-706. (SCI; Impact Factor =8.058)
  6. Ding SL, Yu JC, Chen ST, Hsu GC, Hsu HM, Ho JY, Lin YH, Chang CC, Fann CS, Cheng CW, Wu PE, Shen CY. Diverse associations between ESR1 polymorphism and breast cancer development and progression. Clin Cancer Res 2010;16(13): 3473-3484. (SCI; Impact Factor =6.747
  7. Yu JC, Hsiung CN, Hsu HM, Bao BY, Chen ST, Hsu GC, Chou WC, Hu LY, Ding SL, Cheng CW, Wu PE, Shen CY. Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development. Breast Cancer Research 2011;13(1):R13 (SCI; Impact Factor =5.33)
  8. Hsu MS, Yu JC, Wang HW, Chen ST, Hsiung CN, Ding SL, Wu PE, Shen CY, Cheng CW. Synergistic Effects of Polymorphisms in DNA Repair Genes and Endogenous Estrogen Exposure on Female Breast Cancer Risk. Ann Surg Oncol 2010;17(3):760-771.(SCI; Impact Factor =4.130
  9. Ding SL, Yu JC, Chen ST, Hsu GC, Kuo SJ, Lin YH, Wu PE, and Shen CY. Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. Carcinogenesis 2009; 30(1):43-49. (SCI; Impact Factor =5.406
  10. Yu JC, Ding SL, Chang CH, Kuo SH, Chen ST, Hsu GC, Hsu HM, Hou MF, Jung LY, Cheng CW, Wu PE, Shen CY. Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell-cycle and ubiquitin ligase genesCarcinogenesis 2009; 30(9):1562-1570(SCI; Impact Factor =5.406)
  11. Ding SL, Yu JC and Shen CY. Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes. Clinical Interventions in Aging 2008; 3(3): 1–14.
  12. Ding SL, Yu JC and Shen CY. Mutational Screening of BRCA1 Gene on 93 Early-onset Breast Cancer Patients in Taiwan. Academic Journal of Kang-Ning 2008;10:1-23.
  13. Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shief SY, Shen CY. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J2008;27:3140-3150.(SCI; Impact Factor =8.662
  14. Bau DT, Mau YC, Ding SL, Wu PE, Shen CY. DNA Double-Strand-Break Repair Capacity and Risk of Breast Cancer. Carcinogenesis 2007; 28(8):1726-1730. (SCI; Impact Factor =5.108
  15. Ding SL, Yu JC, Chen ST, Hsu GC, Shen CY. Genetic Variation in the Premature Aging Gene, WRN: a Case-Control Study on Breast Cancer Susceptibility. Cancer Epidemiology, Biomarkers and Prevention 2007; 16 (2):263-269. (SCI; Impact Factor =4.642
  16. Ding SL, Sheu LF, Yu JC, Yang TL, Chen BF, Leu FJ and Shen CY. Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade. British Journal of Cancer 2004; 90: 1995-2001. (SCI; Impact Factor = 4.635
  17. Ding SL, Sheu LF, Yu JC, Yang TL, Chen BF, Leu FJ and Shen CY.  Expression of estrogen receptor-α and Ki67 in relation to different pathological and molecular features in early-onset infiltrating ductal carcinoma. J BioMed Sci 2004; 11(6): 911-919. (SCI; Impact Factor =2.024
  18. Chen A, Sheu LF, Ding SL, Shaio MF, Lee WH. Antiidotype directly interferes with the glomerular localization of IgA immune complexes. Nephron 1998; 78:234-243. (SCI; Impact Factor =13.26
  19. Ding SL, Yen LL. Behavioral factors related to motorcyclists head injuries, with emphasis on high-risk group. Public Health 1996; 23:239-246.
  20. Chen A, Chu WY, Sheu LF, Wei CH, Ding SL, Lee WH. Induction of proteinuria by adriamycin, bovine serum albumin or puromycin aminonucleoside in themouse. Nephron 1995; 69:293-300. (SCI; Impact Factor =13.26
  21. Ding SL, Wang JD, Chen KT. Epidemiological analysis of 845 cases of pedestrian traffic injuries. Chin Med J 1994; 53:16-22.
  22. Ding SL, Pai L, Wang JD, Chen KT. Head injuries in traffic accidents with emphasis on the comparisons between motorcycle-helmet users and non users. J Formosan Med Assoc 1994; 93:s42-48.
  23. Ding SL, Pai L, Hsu WL. The premature years of potential life lost and sex differences on main causes of death in Taiwan. J Med Sci 1994; 14:397-404.
  24. Ding SL, Pai L, Hsu WL. Medical Statistics: survival analysis. Medical Digest 1994; 18:406-410.
  25. Chen A, Ding SL, Song YB, Chou WY, Shau MF. Experimental IgA nepheopathy: enhancement of glomerular IgA immune complex deposition in heavy proteinuric state. Lab Invest 1994; 70:639-647.(SCI; Impact Factor =4.405
  26. Ding SL, Hsu WL. Cancer registrationfunctions and objectives. Medical Digest 1993; 17:542-545.
  27. Ding SL, Hsu WL. Trend of three leading cause of death in Taiwan. Medical Digest 1993; 16:156-162.
  28. Chen TK, Yao CT, Chen LT, Hwang WS, Ding SL. Surgical treatment of pancreatic adenocarcinoma in Taiwan. Asian J Surgery 1993; 16:289-293. (SCI; Impact Factor =0.52